Medicinal Chemistry & Chemistry Services
Our scientific team has a thorough synthetic organic chemistry base and is capable of handling a variety of chemistry and biotechnology projects over a diverse chemical structure class.
Our chemists routinely perform synthesis from 1 mg to Kilo scale and major emphasis is on synthesis that involves economical, environmentally benign and readily available starting materials and reagents. We believe in is timely delivery with uncompromised quality.
Every deliverable target product and intermediates are typically characterized using state-of-the-art analytical techniques (Infrared spectroscopy, 1H & 13C, 19F, 31P NMR, 2D-NMR techniques such as 1H-1H COSY, HMBC, HSQC, NOE difference, LC-MS and HPLC).
Our services for medicinal chemistry/synthetic chemistry include:
- Hit to lead optimization employing standard SAR approaches
- Synthesis of focused Libraries (small and mid size), experienced with scavenger approach for improving purification and isolation for larger set
- Synthesis of Reference Standards; Building Blocks; Analogues; Intermediates and specially designed Lead Molecules
- Impurity profiling according to customer’s requirement including structural elucidation of unknown impurities
PROCESS R&D: We excels in compacting the discovery and development time through efficient and cost-effective. We provide R & D for Processing, Early clinical manufacturing of pharmaceutical drug and we are capable of producing API needed for preclinical toxicology etc.
Analytical Services: Meduant can provide needed for Routine Assay. Raw material characterization as per latest Pharmacopoeia (USP, BP, EP, IP, JP) Method development as per ICH guidelines. Method validation as per ICH guidelines. Impurity isolation and characterization. Trace metal analysis using AAS and ICP-MS techniques Organic Volatile Impurities and Residual Solvents as per USP. Heavy metals Extractable and Leachable analysis
CHIRAL CHEMISTRY: We specialize chiral/asymmetric/stereo selective synthesis and our staff is well knowledge and keeps themselves abreast of latest developments in chiral synthesis to identify the best synthetic route to get pure enantiomer.
Our capabilities: Asymmetric Synthesis, Enantioselective, catalysis,Chiral auxiliaries, Biocatalysis using immobilized lipases, Enantioselective, organocatalysis, Chiral pool synthesis, chiral resolution of racemates,
SPECIALTY CHEMISTRY: We acquired in-depth knowledge, by virtue of our long work experience in specialized chemistry and we offer our services covering hydrophobic to hydrophilic compounds with or without chromophores.
We offer our services in: Synthesis of Lipid/Sphingolipids via de novo synthesis or functional group manipulations.
Synthesis of Nucleoside bases and their elaboration to nucleosides via glycosylation and further transformation to Nucleotides (mono-phosphates, tri-phosphates etc.).
Synthesis of Imino sugar, Glycosyl acceptors/donors, Oligosaccharides – tri and tetra and functional group transformations on carbohydrates.
Functional group transformation on Steroidal skeletons, synthesis of novel Peptides using solution phase as well as solid phase.
PEG related compounds
Multistep stereo-selective & specific synthesis of natural products (Macroketone/Macrolides and Alkaloids) and their analogues having several asymmetric centers,
Site specific labeling of compounds with cold labels (D, 13C and 15N). Conjugation of small molecules with Biotin or other fluorescent probes.
Organometallic reagents -Synthesis of catalysts and pre-catalyst using Rh and Pd metals VALUES. We dedicate ourselves to better our services continuously with the motto of utmost satisfaction and thus to meet the expectations of our clients.
Our endeavor is to excel in every assignment we undertake on behalf of our valued clients and we believe in not resting on the laurels as we always strive to better ourselves.